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Paget's disease of bone

Find about the main tests used to diagnose Paget's disease of bone, including blood tests, X-rays and scans.

Paget's disease of bone can be diagnosed with a blood test and an X-ray or scan.

These are outlined below.

Blood test

A simple blood test can be carried out to check the level of a substance called alkaline phosphatase (ALP) in your blood.

People with Paget's disease of bone often have raised levels of ALP, although some people with the condition have a normal ALP level and a high level can also be caused by some other conditions.

An X-ray or scan is therefore also needed to confirm the diagnosis.

X-ray and bone scan

An X-ray can show whether your bones have become enlarged as a result of Paget's disease of bone.

Sometimes a special type of bone scan called scintigraphy may also be carried out to check how much of your body is affected by the condition.

For this scan, a small amount of a radioactive substance is injected into your blood. This collects in areas where there's a lot of bone renewal taking place.

A special camera known as a gamma camera is then used to detect the radiation and highlight affected parts of the body.

Further tests

Further tests are usually only needed if you have signs of more severe Paget's disease of bone or your doctor thinks there's a chance you could have bone cancer (although this is very rare).

In these cases, you may be advised to have a:

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